Loctite Corporation began in the Trinity College basement laboratory of Dr. Vernon Krieble of Hartford, Connecticut in 1953. This entrepreneurial chemistry professor developed a cure inhibition system for a unique bonding resin that hardened in the absence of air- an anaerobic sealant.

Loctite® made its official public debut at a press conference at the University Club in New York on July 26, 1956. The promise of solving the age-old problem of loose nuts and bolts in machines and appliances – a problem customers had long ago accepted as unsolvable – led to an incredible flow of inquiries.

In the 1960s, cyanoacrylates – also known as CA or “Superglue”, a very fast, one-part, room-temperature curing type of industrial adhesive – were added to the Loctite® brand. Silicones, epoxies, acrylics and the development of further generations of Loctite® anaerobics and cyanoacrylate technology and products followed

Throughout its history, Loctite® has continuously created markets by discovering opportunities where no one knew they existed. From its founding, based on a product that solved an "unsolvable" problem, Loctite® has achieved success through innovation.

In 1997 Loctite has been acquired by Henkel and remains a primary brand.